With Galactus defeated and Dr. Doom moping behind bars, Super Hero City is finally safe, that is, until Thanos goes in search of the powerful Infinity Gauntlet. Although they are without their comrade-in-laughter, Silver Surfer, the Super Hero Squad, Iron Man, Thor, Hulk, Wolverine and Falcon, must once again come together to take on any villainy that threatens the peace and safety of the Marvel universe - no matter where it might take them.

Hungry for adventure, Thor secretly embarks on the journey of a lifetime, joined by his loyal brother Loki, whose budding sorcery equips him with just enough magic to conjure up trouble, along with the Warriors Three, a band of boastful travelers reluctant to set sail on any adventure that might actually be dangerous. But what starts out as a harmless treasure hunt quickly turns deadly, and Thor must now prove himself worthy of the destiny he covets...

After 74 villains break out of prison, Marvel's most powerful superheroes team up to capture all of them, and also to defend the Earth from widespread threats.